The youngster made a surprise start along with Tom Lawrence, and both impressed in a comfortable United win, with Robin van Persie bagging the other goal on his return.
Wilson almost scored just two minutes in but badly scuffed his shot after being teed up by Adnan Januzaj, but the Belgian put in a supreme performance, creating chances at will with his penetrating runs. Yet it was another Belgian, Marouane Fellaini - who had an otherwise woeful performance - who provided the assist, chesting down a set-piece for young Wilson to smash home with an instinctive finish.
Januzaj continued to tear Hull apart in the second half and created the second goal, after skipping away down the right wing and cutting the ball back for Fellaini. The curly one's effort was poor, but Wilson was there to scoop home the rebound and double his tally.
Matty Fryatt scored with a sensational strike out of nothing taking advantage of some poor defending from Michael Carrick just afterwards, but United didn't take too long to re-assert their dominance.
There was to be no hat-trick for Wilson, as Giggs subbed him off shortly thereafter and brought himself on with enough time remaining for one last home goal. Sadly, it didn't come - a penalty shout was turned down, and a late free-kick was clawed out by the Hull keeper, but Giggs had to settle for an assist, teeing up Robin van Persie to power home and complete the scoring.