First, the good news: Phil Jones starts in midfield, and Spurs defence of Chiriches and Dawson with Vertonghen at left-back looks a bit of a disaster.
Then, the middling news: Shinji Kagawa starts in the hole, Danny Welbeck starts on the left, and Rafael returns to the bench (excellent news if he's not quite fit, terrifying news if he is.) Spurs' midfield three of Sandro, Paulinho and Mousa Dembele looks a bit off, too, as does Nacer Chadli starting.
Then, the bad: There's no Adnan Januzaj in the squad at all, Smalling continues at right-back, Ashley Young and Anderson are granted a place on the bench, Tom Cleverley starts, there's no Robin van Persie.
So, a mixed bag. Difficult to say what will happen, and the lack of Januzaj is a worry regardless of the reasons. Nonetheless, there's nothing to suggest imminent disaster here, but we'll see how it goes.
Manchester United starting lineup: David De Gea; Chris Smalling, Nemanja Vidic, Jonny Evans, Patrice Evra; Tom Cleverley, Phil Jones; Danny Welbeck, Shinji Kagawa, Antonio Valencia; Wayne Rooney.
Subs: Anders Lindegaard, Rafael, Anderson, Marouane Fellaini, Nani, Ashley Young, Javier Hernandez.