The wantaway striker is a surprise, and brave inclusion by David Moyes, who lines up behind Robin van Persie, with Danny Welbeck and Antonio Valencia on the wings.
Unusually, Wilfried Zaha is not in the squad, while Shinji Kagawa is on the bench. Phil Jones somewhat surprisingly continues in place of Rafael at right-back despite some questionable recent performances.
Chelsea, meanwhile, line up with Andre Schurrle up front, with Frank Lampard and Ramires in midfield. Juan Mata is still absent from the side, as is John Obi Mikel, who is also injured.
Manchester United starting line-up: David de Gea, Phil Jones, Rio Ferdinand, Nemanja Vidic, Patrice Evra; Michael Carrick, Tom Cleverley; Danny Welbeck, Wayne Rooney, Antonio Valencia; Robin van Persie.