The youngster is given a start in a key position behind Danny Welbeck, with Ashley Young on the left wing. Antonio Valencia continues on the right.
Phil Jones also comes back into the team to partner Michael Carrick in midfield - a risk, given how little he's played recently, with Darren Fletcher on the bench.
Meanwhile, Chelsea have new signing Nemanja Matic on the bench, with Gary Cahill in defennce and David Luiz versus Ramires in midfield. Samuel Eto'o starts up front.
Manchester United stating lineup: David De Gea; Patrice Evra, Jonny Evans, Nemanja Vidic, Rafael; Michael Carrick, Phil Jones; Ashley Young, Adnan Januzaj, Antonio Valencia; Danny Welbeck.
Subs: Anders Lindegaard, Ryan Giggs, Chris Smalling, Javier Hernandez, Tom Cleverley, Darren Fletcher, Shinji Kagawa
- Manchester United linked with move for Everton star
- Revealed: the world-class striker United want to replace Rooney, according to report
- Anderson completes move to Fiorentina
- Manchester United "confident" of completing Gundogan transfer
- Manchester United's Wayne Rooney unavailable for Chelsea, says David Moyes