Shinji Kagawa and Adnan Januzaj are on the wings, with Michael Carrick and Darren Fletcher in midfield. Javier Hernandez and Danny Welbeck both start up front in a 4-4-2, while Chris Smalling takes the place of the injured Nemanja Vidic in defence alongside Jonny Evans. Alexander Buttner also takes Patrice Evra's place at right-back.
Meanwhile, Juan Mata starts in the 'about to sign for Manchester United, inspire a brilliant second-half late title push and sweep aside our rivals like so much dust and debris, breaking the hearts of small-minded Chelsea fans as he does' role.
Manchester United starting lineup: David de Gea, Rafael, Jonny Evans, Chris Smalling, Alexander Buttner; Shinji Kagawa, Michael Carrick, Darren Fletcher, Adnan Januzaj; Javier Hernandez, Danny Welbeck.
Subs: Anders Lindegaard, Patrice Evra, Phil Jones, Tom Cleverley, Ryan Giggs, Ashley Young, Antonio Valencia.
Sunderland starting lineup: Mannone, Bardsley, Alonso, Brown, O'Shea (c), Cattermole, Colback, Ki, Johnson, Borini, Fletcher.