Januzaj comes in for Radamel Falcao, who is apparently suffering from jetlag after international duty.
Also of note is the inclusion of Michael Carrick on the bench, and the absence of Paddy McNair from the squad. Phil Jones starts at centre-back alongside Marcos Rojo. Otherwise, there are few surprises in the United selection.
Manchester United starting lineup (4-2-3-1): David De Gea; Luke Shaw, Marcos Rojo, Phil Jones, Rafael; Daley Blind, Ander Herrera; Ángel Di María, Juan Mata, Adnan Januzaj; Robin van Persie.
Subs: Anders Lindegaard, Chris Smalling, Michael Carrick, Darren Fletcher, Ashley Young, Radamel Falcao.
West Bromwich Albion starting lineup (4-2-3-1): Boaz Myhill; Sébastien Pocognoli, Craig Dawson, Joleon Lescott, Andre Wisdom; Craig Gardner, James Morrison; Chris Brunt, Stéphane Sessègnon, Graham Dorrans; Saido Berahino.