The trio of attacking stars Juan Mata, Wayne Rooney and Robin van Persie all start, with Ashley Young out left in a similar shape to what we saw at Stoke City last week.
There are a few ex-Reds in the Fulham team to look out for, including coach-turned-manager René Meulensteen, and intriguingly also former United youngster Ryan Tunnicliffe, who starts in midfield for the Cottagers.
As ever, chat away in the thread below. I'm going to take cover behind my sofa.
Manchester United confirmed starting lineup: David De Gea; Patrice Evra, Nemanja Vidić, Chris Smalling, Rafael; Ashley Young, Darren Fletcher, Michael Carrick, Juan Mata; Wayne Rooney; Robin van Persie.
Subs: Anders Lindegaard, Rio Ferdinand, Ryan Giggs, Antonio Valencia, Shinji Kagawa, Adnan Januzaj, Javier Hernández.
Fulham confirmed starting lineup: Maarten Stekelenburg; John Arne Riise, Jonny Heitinga, Dan Burn, Sascha Riether; Kieran Richardson, William Kvist, Steve Sidwell, Ryan Tunnicliffe; Lewis Holtby; Muamer Tanković.