Wayne Rooney missed both of England's games with an injury, but should return to action for United as he returns to his former club Everton. Rooney has notoriously underperformed in these matches which, when multiplied by how terribly he is already playing, means we may see the very worst performance of all time by any player, ever.
Daley Blind and Memphis will both be looking to get over the disappointment of the Netherlands failing to qualify for Euro 2016, and Paddy McNair remains out with a ruptured liver suffered while playing for Northern Ireland. Marcos Rojo missed Argentina's games with an injury of his own.
Apart from those injuries, and obviously Luke Shaw, United can call on the rest of their squad, so the selection should be fairly predictable. With Phil Jones, Antonio Valencia and Matteo Darmian, there may be a change at right-back, and it remains to be seen which of the two central midfielders Louis van Gaal will start at Goodison Park.
Everton have started well this season, and Ross Barkley is in impressive form. Along with Romelu Lukaku, he is the biggest threat for Everton. Pace, skill and power - all of these things are like kryptonite to United's defence. So get excited!
You can read Jack Sargeant's match preview here.
When: Saturday 16 October, 3pm UK time, 10am ET.
Where: Goodison Park, Liverpool
How to watch: In the UK, you can't. In the US, NBCSN.
How to watch online: In the UK you can't do it without getting a call from the rozzers. In the US, NBC Online.