Manchester United will retain first place should they win against Arsenal, or go one point behind Manchester City should they draw. If Arsenal pull off a massive victory over United they could possibly leapfrog United into second place.
Manchester United have injury worries with Marcos Rojo and Paddy McNair, while Luke Shaw is a long-term absence with a broken leg. Antonio Valencia, Ashley Young and Matteo Darmian are probably the options at full-back, with two chosen from those three, though Phil Jones might make a full start after returning as a substitute against Wolfsburg.
Wayne Rooney, Memphis, Juan Mata and Anthony Martial will probably be the front four, with two from Michael Carrick, Morgan Schneiderlin, Ander Herrera and Bastian Schweinsteiger the midfield options.
You can read Jack Sargeant's preview of the match here.
Where: Emirates Stadium, London.
When: 4pm GMT, 11am ET.
How to watch: NBCSN (US)/Sky Sports 1 (UK).
How to watch online: NBC Sports Live Extra (US)/Sky Go (UK)
Subs: Romero, Jones, McNair, Schneiderlin, Valencia, Fellaini, Wilson #mufc— Manchester United (@ManUtd) October 4, 2015