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Manchester United manager Louis van Gaal is expected to start out-of-favour Memphis as injuries start to mount.
In attack, Anthony Martial and Wayne Rooney are both injured after international duty, and Marouane Fellaini has been unable to recover from an injury which prevented him playing for Belgium last week.
Antonio Valencia is out for several months after a foot operation, and Luke Shaw continues his rehabilitation from a broken leg. The midfield is not spared from problems, with Michael Carrick recovering from a slightly ligament injury after playing for England.
James Wilson may feature in attack, but Van Gaal has admitted that he is not match fit having barely featured this season, something which Van Gaal is essentially to blame for, almost excommunicating him to the reserve team.
HOW TO WATCH
When: Saturday 21 November 2015, 12.45pm GMT, 7.45 am ET
Where: Vicarage Road, almost in London
Television: BT Sport 1 in the UK, NBC for the US
Online: BT Online in the UK, NBC for the US (see hyperlink for stream)