Manchester United take on PSV Eindhoven as they look to secure Champions League group stage qualification.
PSV have been the only side to beat United in the Champions League this season, and when the two sides played one another in the Netherlands, it was Hector Moreno's ridiculous tackle which broke Luke Shaw's leg.
United's injury list has continued to grow, with Phil Jones and Ander Herrera likely unavailable for Wednesday's match. Anthony Martial's knock, suffered on international duty, could keep him out for another match. Wayne Rooney was too ill to play against Watford, but should be fit for the next match.
With Memphis scoring against Watford it seems likely that he will remain in attack, and Rooney can replace the injured Herrera at 10. Marouane Fellaini could feature to give Bastian Schweinsteiger a rest, with Leicester City to play next Saturday evening, but he too is injured and not certain to be available.
The defence will be missing Jones, Antonio Valencia and Shaw, so Blind, Rojo and Darmian are the options on the left side of the defence. It seems unlikely Louis van Gaal will persist with three at the back. What is your preferred line up?
Subs: Romero, Rojo, McNair, Fellaini, Pereira, Martial, Wilson.