Manchester United look to build on a successful start after the international break by beating PSV, and securing Champions League qualification.
They will have to do this with a side missing several players through injury. Luke Shaw and Antonio Valencia are long term absentees, and Shaw has been given four days off, timed to coincide with the game against the opponents who broke his leg.
Bastian Schweinsteiger and Ander Herrera didn't train with the team yesterday, but Anthony Martial and Wayne Rooney both did, recovering from injury and illness respectively.
Marouane Fellaini, Michael Carrick and Phil Jones all have slight injuries, and so are doubtful for the match, and youngsters were called up to the first-team training session yesterday.
HOW TO WATCH
When: Wednesday 25 November 2015, 19.45pm GMT, 2.45 pm ET
Where: Old Trafford, Manchester
Television: BT Sport in the UK, NFox or the US
Online: BT Online in the UK, Fox or the US