With Rojo injured, there have been suggestions of a return to the 3-5-2 system that the players failed to adapt to last season, and which was one of the reasons for Watford to come back into a match that they had been struggling in.
Paddy McNair, Daley Blind and Chris Smalling are the only fit central defenders, and it is unclear if Ander Herrera will return to bulk up the attack in Lingard's absence. Wayne Rooney will captain the side, with the injury crisis the latest excuse to keep him in the eleven.
Two in attack would, at least, force more of an attacking presence for Untied, against Leicester, who have one of the worst defensive records in the league. A rejigged defence could give Jamie Vardy plenty of room to exploit in order to beat his and Ruud van Nistelrooy's shared scoring record.
HOW TO WATCH
When: 5.30pm (UK), 12.30pm ET (US)
Where: King Power Stadium, Leicester
Television: Sky Sports 1 (UK), NBC (US)
Online: Sky Go (UK), NBC Online (US).