Matteo Darmian's run of bizarrely poor form has led to his replacement by Ashley Young, while Michael Carrick makes an unwelcome yet not unsurprising return to the midfield in the absence of Morgan Schneiderlin.
Ander Herrera has been left on the bench despite his recent good performances (perhaps, like Phil Jones, he's in the scary sounding 'red zone'), meaning Jesse Lingard is given a start out on the right side of the attack. Poor Memphis Depay: this really wasn't how he must have envisaged things panning out. He's benched.
And, as ever, Wayne. Rooney. Is. Up. Front.