Manchester United take on West Ham United in the Premier League with their injury difficulties continuing to hamper the side.
United have played with a 3-5-2 formation against Watford and Leicester City, but the poor attacking performance from Matteo Darmian might be more likely to see a change in formation rather than a change in personnel, simply because options are so limited. A return to four in defence would also mean that Marcos Rojo - out for several weeks with a shoulder injury - would not be so keenly missed. With Paddy McNair also receiving criticism for trying to attack, he may fall victim to Louis van Gaal's whims.
In midfield, Morgan Schneiderlin may feature alongside Bastian Schweinsteiger, who if he features, will likely be removed around the hour mark to keep him fresh for the match against Wolfsburg in the Champions League.
Wayne Rooney has a slight knock, but with only Memphis, Juan Mata and Anthony Martial certain to be fit in attack for United, he will probably keep his place ahead of the more severely injured Ander Herrera. Jesse Lingard is a doubt, and James Wilson has been sent on loan to Brighton.
Subs: Romero, McNair, Borthwick-Jackson, Pereira, Carrick, Fellaini, Rashford.