Wayne Rooney is an absentee for Manchester United against West Ham today, and he may be kept out of the Champions League game against Wolfsburg, too.
Ander Herrera continues to be out injured, so Jesse Lingard's return to fitness should see Juan Mata move into the number 10 role, with Anthony Martial as striker, and Memphis and Lingard on the wings.
Phil Jones is unlikely to feature, and Marcos Rojo is out injured after suffering a serious shoulder injury which could keep him out for weeks. Antonio Valencia and Luke Shaw are long-term injuries for United.
In midfield, Morgan Schneiderlin may make a return, though Michael Carrick and Bastian Schweinsteiger could continue their partnership.
HOW TO WATCH
When: 3pm, UK / 10am ET
Where: Manchester, England
TV: You can't watch it in the UK, but NBC have it in the US.
Online: There are no legal streams in the UK, but you can watch it on NBC using this link.
United: David de Gea; Matteo Darmian, Paddy McNair, Chris Smalling, Daley Blind; Bastian Schweinsteiger, Morgan Schneiderlin; Juan Mata, Marouane Fellaini, Jesse Lingard; Anthony Martial
Subs: Sergio Romero, Cameron Borthwick-Jackson, Guillermo Varela, Michael Carrick, Andreas Pereira, Ashley Young, Memphis Depay
West Ham: Adrian, Tomkins, Reid, Ogbonna, Cresswell, Song, Noble, Kouyate, Moses, Zarate, Carroll
Subs: Randolph, Jenkinson, Collins, Obiang, Oxford, Antonio, Jelavic