So, Louis van Gaal appears to have relented to make use of four at the back with a diamond, but he's still holding out over Ander Herrera, sadly.
Paddy McNair is also dropped despite an excellent display against Cambridge United, but the team otherwise looks a solid one. Other than that, the big news is that Falcao starts, partnering Robin van Persie up front.
Manchester United starting lineup: David De Gea, Antonio Valencia, Phil Jones, Marcos Rojo, Luke Shaw, Daley Blind, Wayne Rooney, Adnan Januzaj, Angel Di Maria, Falcao, Robin van Persie.
Subs: Valdes, Herrera, Fellaini, Wilson, McNair, Blackett, Mata.
How to watch
Match time: 4:15 p.m. GMT, 11:15 a.m. ET
Venue: Upton Park, London
TV: If you're in the UK, then you'll need to tune in to Sky Sports 1/HD to watch the action, or you can catch it online if you have a Sky Go subscription. Radio commentary is on BBC 5 Live to listen. Over in the US, we believe it's on NBC and NBC Sports Live Extra, as well as a couple of Spanish language options. Everybody else, head on over to LiveSoccerTV for your information.