Rooney played for the Under-21s on Monday night and Louis van Gaal has sufficiently broken both Juan Mata and Marcus Rashford to make a return for his chief Yes Man to return to the starting eleven.
West Ham are favourites due to their recent 3-3 draw with Arsenal, where Andy Carroll scored a hat-trick, and also because they are a better team with a better manager than United and Van Gaal.
Timothy Fosu-Mensah left with a knock against Spurs and it's not certain he will return for the game at the Boleyn Ground, and it is worth keeping an eye on which players are dropped from Sunday. Not because they lost - it's hardly like Van Gaal to change someone for poor performances is it, Wayne? - but because of stories of dissent in the ranks.
How to watch
When: Wednesday 13 April 2016, 7.00pm BST, 2.00pm EST.
Where: Boleyn Ground, London
Television: BBC1 in Britain, Fox Sports 2 in USA
Online: BBC iPlayer in Britain, Fox Soccer 2GO