While United just about have something still to play for, it's a dead rubber for a Palace side who have staggered over the line to safety. The Eagles have won only a solitary league game since the turn of the year, yet still find themselves a fairly healthy nine points above the drop.
United will have Ander Herrera back fit for the match, as confirmed by Louis van Gaal in his press conference yesterday, while the Reds, rather amazingly, have no fresh injury concerns in the aftermath of their underwhelming victory over Aston Villa on the weekend.
How to watch
When: Wednesday, 20 April 2016, 8 pm BST, 3 pm EST.
Where: Old Trafford, Manchester
Television: Nowhere in Britain, DirecTV in USA
Online: Nowhere in Britain, NBC Online in USA