There has been a general clamouring from fans for Rooney to be dropped from the side in recent weeks, following a string of below-par performances, and manager José Mourinho has decided the time has come to remove his skipper from the staring XI.
Luke Shaw also misses out, having picked up a minor groin injury in the defeat to Watford last week; Daley Blind starts at left-back.
Jesse Lingard returns to the side for the first time since being substituted at half time in the Manchester derby two weeks ago, with Marcus Rashford also starting.
Mourinho’s selection suggests a move back to a 4-2-3-1 formation, having experimented with 4-3-3 in the last three games.
United line up as follows: De Gea; Valencia, Bailly, Smalling, Blind; Pogba; Herrera; Lingard, Mata, Rashford; Ibrahimovic
United’s bench: Romero, Fosu-Mensah, Rojo, Carrick, Fellaini, Young, Rooney
Leicester go with: Zieler; Simpson, Morgan, Huth, Fuchs; Mahrez, Amartey, Drinkwater, Albrighton; Vardy, Slimani