Axel Tuanzebe suffered an injury during the warm-up ahead of the match against Liverpool, but his hip appears to have recovered to give him a chance of featuring in defence for Ole Gunnar Solskjaer.
Scott McTominay was injured during the 3-1 win against Brighton and Hove Albion and he has not yet recovered from his ankle problem, meaning that United are set to play without their best midfielder so far this season. He did not feature in either of Scotland’s international games during the recent break.
Nemanja Matic, linked with a move to Tottenham Hotspur now that Jose Mourinho has been installed as the new manager to replace Mauricio Pochettino, could make his return in McTominay’s absence, but it is unclear what the state of the relationship is between midfielder and manager.
Paul Pogba remains sidelined, and he also missed out on international duty, though he could be back at some point in December. There remains speculation that he may leave in the winter transfer window and has been linked to both Real Madrid and Juventus, meaning there is a chance that the World Cup winner will not play another game for United.
Luke Shaw is also back to training, but is unlikely to feature. Tuanzebe has been a better left-back than Shaw this season, Brandon Williams could have made himself the first choice in the position for the foreseeable future. It is even less likely that Shaw will feature because Ashley Young is back from suspension.
United are aided by the fact that their on-loan goalkeeper Dean Henderson will not be able to feature for Sheffield United, because he is ineligible to play against his parent club.