Fred and Edinson Cavani are set to miss Manchester United's game against Leicester City on October 16 due to international fixture scheduling— utdreport (@utdreport) October 6, 2021
Brazil are set to face Uruguay on Friday with a 1:30am kick-off (BST), with the short turnaround between that time and United’s Saturday fixture at 3pm meaning Fred and Cavani are unlikely to be ready to play.
BBC reporter Simon Stone suggests that United expects both players to feature in all three international games over the current break, meaning they will not be called upon without adequate preparation time for the trip to the King Power Stadium.
Along with others, Man Utd expecting Fred and Edinson Cavani to play in all three South American WC qualifiers, first one overnight, third 0130 kick-off BST next Friday morning, so little chance of them being involved at Leicester the following day.— Simon Stone (@sistoney67) October 6, 2021
Nemanja Matic and Paul Pogba are among the options to replace Fred in central midfield, with Scott McTominay also a frequent starter. Ronaldo is likely to start up front, so barring bad injury luck Cavani’s absence shouldn’t be too big of a problem.